Which early signs of agranulocytosis should a client receiving Clozaril report?

The early signs of agranulocytosis, especially in patients taking Clozaril (Clozapine), typically include symptoms that suggest a significant decrease in white blood cell count, leading to increased vulnerability to infections. The correct answer highlights lethargy, weakness, fever, sore throat, and malaise, which are classic indicators a patient might experience.

Lethargy and weakness can indicate overall fatigue and reduced energy, while fever is a common sign of infection due to the immune system's compromised state. A sore throat often signifies the onset of an infection, especially in the context of agranulocytosis where a person's ability to fight infections is impaired. Malaise, or a general feeling of being unwell, can also accompany this condition, further signaling the need for immediate medical attention.

In contrast to the other options, the symptoms listed are more closely related to immune deficiency and the body's response to potential infection stemming from a lack of neutrophils, which is critical in fighting off illnesses. The other choices do not reflect the primary concerns associated with agranulocytosis in the same direct way. Symptoms such as nausea, vomiting, or dizziness typically do not convey the same urgency regarding immunological concerns and may indicate different health issues