What might indicate a need for a physician’s intervention during drug therapy for gastrointestinal side effects?

Severe diarrhea during drug therapy can be a significant indicator that a physician's intervention is necessary. This is because severe diarrhea can lead to dehydration, electrolyte imbalances, and nutrient malabsorption, all of which pose serious health risks. It may also interfere with the effectiveness of the medication being taken, as it can affect the absorption of drugs and possibly lead to complications.

In contrast, increased appetite, occasional discomfort, and mild nausea may not warrant immediate medical intervention. While they can certainly be uncomfortable or concerning, these symptoms are often less acute and can sometimes be managed through lifestyle changes, dietary adjustments, or over-the-counter medications without the need for a physician's involvement. Therefore, the severity and potential complications associated with severe diarrhea underscore the importance of medical evaluation and prompt intervention.