What happens if a patient increases their sodium intake beyond 10 grams a day while on lithium?

When a patient increases their sodium intake beyond 10 grams a day while on lithium, it leads to an increase in lithium excretion, which subsequently reduces the drug's effect. Lithium is a mood stabilizer commonly used to treat bipolar disorder, and its concentration in the blood is closely linked to sodium levels. When sodium intake is high, the kidneys excrete more lithium to maintain the balance of electrolytes in the body. This means that as sodium goes up, lithium levels in the bloodstream can drop, potentially leading to a decrease in the therapeutic effects of lithium treatment. It's crucial for patients on lithium to maintain a consistent sodium intake, as fluctuations can significantly impact the drug's efficacy and safety.